Twelve people have died in a west London tower block fire and the number of deaths is expected to rise, police have said.
Firefighters rescued 65 people from Grenfell Tower in north Kensington, after they were called at 00:54 BST.
Witnesses said people were trapped in the tower block, screaming for help and yelling for their children to be saved.
Theresa May said there would be a full investigation and “if there are any lessons to be learned they will be”.
It is understood that “several hundred” people would have been in the block when the fire broke out, most of them sleeping.
The ambulance service said 68 patients had been taken to six hospitals across London, with 18 in critical care. A further 10 patients made their own way to hospital.
Eyewitnesses said they saw lights – thought to be mobile phones or torches – flashing at the top of the block of flats.
Trapped residents came to their windows – some holding children.
An emergency number – 0800 0961 233 – has been set up for anyone concerned about friends or family.
Commander Stuart Cundy, of the Metropolitan Police, said: “Sadly I can confirm that there are now 12 people that have died that we know of.
“This is going to be a long and complex recovery operation and I do anticipate that the number of fatalities will sadly increase beyond those 12.”
He said several people were still unaccounted for. “Sadly, I don’t anticipate there will be further survivors,” he said.
London Fire Brigade Assistant Commissioner, Steve Apter, said there were “still pockets of fire yet to be extinguished in places particularly difficult to reach” but “almost all” of the building had been searched.
The service was using drones to help assess the integrity of the building, so the fire service could plan its next steps, he said.
“We certainly intend to be here through the night,” he said.
Checks have been carried out on the building and it is not in danger of collapsing, London Fire Brigade said.
Paul Munakr, who lives on the seventh floor, managed to escape.
“As I was going down the stairs, there were firefighters, truly amazing firefighters, that were actually going upstairs, to the fire, trying to get as many people out the building as possible,” he told the BBC.
He said he was alerted to the fire not by fire alarms but by people on the street below, shouting “don’t jump, don’t jump”.
Eyewitness Jody Martin said: “I watched one person falling out, I watched another woman holding her baby out the window… hearing screams.
“I was yelling at everyone to get down and they were saying ‘We can’t leave our apartments, the smoke is too bad on the corridors’.”